NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia.
DYNASTAT®
(die-na-stat)
parecoxib
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Dynastat powder for injection.
It does not contain all the available information.
It does not take the place of talking to your doctor or nurse.
All medicines have risks and benefits. Your doctor has weighed the risks of you being given Dynastat against the benefits they expect it will have for you.
If you have any concerns about using this medicine, ask your doctor or nurse.
Keep this leaflet with the medicine.
You may need to read it again.
What Dynastat is used for
What Dynastat is for
This medicine is used for the prevention and treatment of pain. It can be used to relieve pain and reduce inflammation (swelling and soreness) which may occur after surgery.
Although Dynastat can relieve the symptoms of pain and inflammation, it will not cure your condition.
Ask your doctor if you have any questions about why this medicine has been prescribed for you.
Your doctor may have prescribed it for another reason.
How Dynastat works
This medicine belongs to a group of medicines called Coxibs.
These medicines work by relieving pain and inflammation.
Using Dynastat
Dynastat is an injection. Only a doctor or nurse can give the injection.
This medicine is available only with a doctor’s prescription.
This medicine is not addictive.
Use in children
There is not enough information to recommend the use of this medicine in children.
Before you are given Dynastat
When it must not be used
You must not be given Dynastat if you have an allergy to:
parecoxib sodium or valdecoxib
any of the ingredients listed at the end of this leaflet
sulphonamides, a group of medicines which include, for example, certain antibiotics (if you are not sure whether you are taking one of these medicines ask your doctor or nurse).
Some of the symptoms of an allergic reaction to Dynastat may include:
asthma, wheezing or shortness of breath
swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing
hives, itching or skin rash
swelling, blistering or peeling of the skin.
These symptoms may be severe if you are allergic to sulphonamides or to any of the ingredients listed at the end of this leaflet and you are given Dynastat.
Ask your doctor or nurse if any of this applies to you.
You must not be given Dynastat if you have had an attack of asthma, hives, itching, skin rash or a runny nose after taking aspirin or Non-Steroidal Anti-Inflammatory Drugs (NSAIDs, medicines used to treat pain and inflammation), including other Coxib medicines.
Many medicines used to treat headache, period pain and other aches and pains contain aspirin or an NSAID.
If you are not sure if you are taking any of these medicines, ask your doctor or nurse.
If you are allergic to aspirin or NSAIDs, including other Coxib medicines and use Dynastat, these symptoms may be severe.
You must not be given Dynastat if you are about to undergo heart or blood vessel surgery.
You should not be given Dynastat if you have had any of the following medical conditions. Your doctor or nurse need to know if you have ever had:
heart disease
a heart attack
a stroke
severe liver problems.
If you are not sure whether you should be given this medicine, talk to your doctor.
Before you are given it
Your doctor and nurse need to know if you have any allergies to:
any other medicines including aspirin or other NSAID medicines, including other Coxib medicines
any other substances, such as foods, preservatives or dyes.
Your doctor and nurse need to know about all your medical conditions, especially if you have ever had any of the following:
kidney or liver problems
heart problems, heart surgery, heart failure, heart attack or other blood vessel disease
stroke
diabetes
high cholesterol levels
high blood pressure
fluid retention or if you are receiving diuretic treatment
dehydration
asthma or other allergic conditions
skin problems with symptoms such as swelling, blistering, peeling, itching, reddening or some other abnormality
peptic ulcer i.e. stomach or duodenal ulcer.
Your doctor and nurse need to know if you are pregnant or intend to become pregnant.
Related medicines, NSAIDs, have been associated with reversible infertility in some women.
Use of NSAIDs in early pregnancy can increase the risk of spontaneous abortion.
Use of Dynastat during pregnancy is not recommended as it may affect your developing baby. Your doctor will discuss with you the benefits and risks of using it.
Your doctor and nurse need to know if you are breastfeeding or intend to breastfeed.
Dynastat passes into breast milk, therefore, breastfeeding should be discontinued during treatment with Dynastat.
Your doctor and nurse need to know if you are a smoker or drink alcohol.
Your doctor and nurse need to know if you currently have an infection.
If you are given Dynastat while you have an infection, it may hide some of the signs of an infection.
If you have not told your doctor and nurse about any of the above, tell them before you are given Dynastat.
Taking other medicines
Some medicines may be affected by Dynastat or may affect how well it works. Your doctor may need to give you different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.
Your doctor and nurse need to know if you are taking any other medicines, including:
all prescription medicines
all medicine bought over-the-counter from a pharmacy or supermarket
all complementary and alternative therapies
any supplements or herbal remedies bought from a health food shop.
Your doctor and nurse need to know if you are taking any medicines used to treat high blood pressure or other heart problems. These include ACE inhibitors, angiotensin receptor antagonists, beta blockers and diuretics (also called fluid or water tablets).
These medicines can cause kidney problems if taken at the same time as you receive Dynastat.
Your doctor and nurse need to know if you are taking any of the following:
aspirin, salicylates or other NSAID medicines used to treat pain, inflammation or swelling
corticosteroids, medicines used to suppress the immune system or reduce inflammation
selective serotonin reuptake inhibitors, medicines used for depression
warfarin or similar medicines including Eliquis (apixaban), Xarelto (rivaroxaban), Pradaxa (dabigatran) or antiplatelet medicines that are used to prevent or stop blood clots from forming
lithium, a medicine used to treat some types of depression
some medicines used to treat diabetes
methotrexate, a medicine used to treat arthritis and some cancers
ciclosporin, a medicine used to suppress the immune system
fluconazole and ketoconazole used to treat fungal infections.
Your doctor and nurse have more information on medicines to be careful with or avoid while using Dynastat.
How Dynastat is given
Your doctor will decide how much Dynastat you need. The usual recommended dose is a single 40 mg injection. Your doctor may adjust the dosage you are given depending on your condition.
Dynastat will be given to you by your doctor. It is diluted and given by injection into a vein through an intravenous line or into a muscle.
Ask your doctor if you want more information about the dose of Dynastat and how it is given.
If you receive too much (overdose)
As your doctor will supervise how much Dynastat you are given, you are unlikely to have an overdose.
If you are given too much Dynastat, you may feel tired, drowsy or sick, or you may be sick, have stomach pains or other abdominal problems.
If you think you have been given too much Dynastat:
tell your doctor or nurse immediately, or
telephone the Poisons Information Centre (telephone 131 126).
While you are receiving Dynastat
Things you must not do
Do not take any other medication unless your doctor is aware of it.
Things to be careful of
Be careful driving or operating machinery after your surgery in case Dynastat has affected you.
This medicine may cause dizziness or light-headedness in some people. If you have any of these symptoms, do not drive, operate machinery or do anything else that could be dangerous.
Side Effects
Tell your doctor or nurse as soon as possible if you do not feel well while you are receiving Dynastat.
This medicine has been prescribed to help you, but it may have unwanted side effects in some people. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.
Do not be alarmed by the following list of side effects.
You may not experience any of them.
Tell your doctor or nurse if you notice anything else that is making you feel unwell.
Other side effects not listed below may also occur in some people.
Tell your doctor…
The following list shows common side effects of Dynastat.
Tell your doctor or nurse if you notice any of the following physical problems and they worry you:
changes in blood pressure
dizziness or light-headedness due to low blood pressure
back pain
ear ache
feeling numb (your skin may lose sensitivity to pain and touch)
stomach upset including nausea (feeling sick), vomiting, heartburn, indigestion, cramps
constipation, diarrhoea, pain in the stomach, wind, bloating
dizziness
sore throat
swollen and sore gums
increased sweating
passing less urine than normal
inflammation and pain after a tooth extraction.
Tell your doctor or nurse if you notice any of the following mental or emotional problems and they worry you:
trouble sleeping
irritability, agitation.
Tell your doctor immediately if…
The following list includes serious side effects which may require medical attention.
Do not be alarmed as you may not experience any of them.
Tell your doctor or nurse immediately if you notice:
a skin rash, including hives, raised red, itchy spots
blistering and bleeding in the lips, eyes, mouth, nose and genitals
swelling, blistering or peeling of the skin, which may be accompanied by fever, chills, headache, sore throat, diarrhoea, aching joints and muscles
swollen glands e.g. under armpit or neck
any other signs of allergic reaction such as wheezing, swelling of the face, lips, mouth, tongue or throat which may cause difficulty in swallowing or breathing
a slow heart beat
a severe or persistent headache, fever, stiff neck, sensitivity to light and vomiting
bleeding or bruising more easily than normal, reddish or purplish blotches under the skin
any signs of anaemia, such as tiredness, being short of breath, and looking pale
an unusual weight gain or loss of appetite
unusual stomach sounds
swelling of lips and tongue
severe stomach or throat pain
joint pain, muscle weakness
you are vomiting blood or having black sticky bowel motions
any infection of, or discharge from, any wounds
complications with skin healing after operations
injection site pain or reaction
yellowing of the skin or eyes (jaundice)
a dry mouth, feeling of thirst and needing to urinate more often
feeling faint or collapse, have shortness of breath, feel tired
have irregular heartbeat, chest pain or discomfort, swollen or sore leg veins.
Product Description
What it looks like
Dynastat is supplied to the hospital in single-use glass vials, and requires dilution with normal saline before use.
It is a white to off-white powder.
Dynastat may also be supplied along with normal saline in glass ampoules for dilution.
When diluted, Dynastat is a clear and colourless solution.
Ingredients
The active ingredient in Dynastat is parecoxib (as parecoxib sodium).
Dynastat contains 40 mg parecoxib per vial.
Dynastat also contains dibasic sodium phosphate, phosphoric acid and sodium hydroxide.
Australian registration numbers
Dynastat 40 mg – AUST R 82525
Dynastat 40 mg with saline diluent – AUST R 82509
Supplier
Dynastat is supplied in Australia by:
Pfizer Australia Pty Ltd
Sydney NSW
Toll Free Number: 1800 675 229
www.pfizer.com.au
This leaflet was prepared in February 2020.
® Registered trademark
© Pfizer Australia Pty Ltd 2020.
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